Department of Health and Human Services, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA.
Int J Obes (Lond). 2011 Dec;35(12):1495-501. doi: 10.1038/ijo.2011.13. Epub 2011 Feb 22.
To investigate the correlation of peripheral insulin concentrations with food intake and body weight.
Cross sectional and longitudinal clinical study: we investigated the association of peripheral insulin concentrations in response to an oral glucose tolerance test (OGTT) with subsequent measures of ad libitum food intake and body weight change.
Food intake analysis: Pima Indians (n=67, 63% male; body mass index (mean ± s.d.) 34.2 ± 9.4 kg m(-2)) with normal glucose regulation (NGR; fasting glucose <5.6 mmol l(-1) and 2-h glucose <7.8 mmol l(-1)) participated in a study of ad libitum food intake measured over 3 days by an automated vending machine system. Weight change analysis: Pima Indians with NGR (n=339) who also participated in a longitudinal study of risks for type 2 diabetes and had follow-up weights.
Food intake analysis: incremental area under the curve (iAUC) for insulin during the OGTT was negatively associated with mean daily ad libitum energy intake (DEI) (r=-0.26, P=0.04), calories consumed as percent weight-maintenance energy needs (%WMEN) (r=-0.38, P=0.002) and carbohydrate intake (gram per day) (r=-0.35, P=0.005). Adjustment for age and sex attenuated the association of iAUC with DEI (P=0.06) not with %WMEN and carbohydrate intake (P=0.005, P=0.008). Weight change analysis: after adjustment for age, sex, follow-up time and initial body weight, higher insulin iAUC predicted less absolute and percent weight change (β=-6.9, P=0.02; β=-0.08, P=0.008, respectively).
In healthy Pima Indians with NGR, higher plasma iAUC during an OGTT predicted lower food intake and carbohydrate consumption and less weight gain. These data indicated a role for peripheral insulin as a negative feedback signal in the regulation of energy intake and body weight.
研究外周胰岛素浓度与食物摄入和体重的相关性。
横断面和纵向临床研究：我们研究了口服葡萄糖耐量试验（OGTT）后外周胰岛素浓度与随后的随意食物摄入量和体重变化测量值之间的关联。
食物摄入量分析：有正常葡萄糖调节（NGR；空腹血糖<5.6 mmol l(-1)且 2 小时血糖<7.8 mmol l(-1)）的皮马印第安人（n=67，63%为男性；体重指数（均值±标准差）为 34.2±9.4 kg m(-2)) 参与了一项通过自动售货机系统测量 3 天随意食物摄入量的研究。体重变化分析：NGR 的皮马印第安人（n=339）还参加了一项 2 型糖尿病风险的纵向研究，并有随访体重。
食物摄入量分析：OGTT 期间胰岛素的增量曲线下面积（iAUC）与平均每日随意能量摄入（DEI）（r=-0.26，P=0.04）、以维持体重所需能量的百分比（%WMEN）（r=-0.38，P=0.002）和碳水化合物摄入量（克/天）（r=-0.35，P=0.005）呈负相关。调整年龄和性别后，iAUC 与 DEI 的相关性减弱（P=0.06），但与%WMEN 和碳水化合物摄入无关（P=0.005，P=0.008）。体重变化分析：调整年龄、性别、随访时间和初始体重后，较高的胰岛素 iAUC 预测体重绝对值和百分比变化较小（β=-6.9，P=0.02；β=-0.08，P=0.008）。
在 NGR 的健康皮马印第安人中，OGTT 期间较高的血浆 iAUC 预测食物摄入和碳水化合物消耗减少以及体重增加减少。这些数据表明外周胰岛素作为能量摄入和体重调节的负反馈信号的作用。
