Clementz B A, Sponheim S R, Iacono W G, Beiser M
Department of Psychology, University of California-San Diego, La Jolla 92093-0109.
Psychophysiology. 1994 Sep;31(5):486-94. doi: 10.1111/j.1469-8986.1994.tb01052.x.
We evaluated the resting electroencephalogram (EEG) of 50 first-episode schizophrenia patients and 55 of their relatives, 31 first-episode bipolar patients and 35 of their relatives, and 113 nonpsychiatric subjects and 42 of their relatives. The frequency characteristics of the EEG showed moderate stability for a subgroup of these subjects (n = 106) who were tested twice, approximately 9 months apart. Both the schizophrenia and bipolar patients showed a generalized pattern of increased delta and theta and decreased alpha activity. The bipolar patients demonstrated additional right hemisphere activity that was not present among the schizophrenia patients and nonpsychiatric subjects, a finding consistent with hypotheses concerning nondominant hemisphere involvement in the regulation of elated mood. The schizophrenia patients' female relatives and/or relatives with affective disorders and the bipolar patients had significantly reduced peak alpha frequencies. This finding may be related to reduced information processing capacity among these subjects.
我们评估了50例首发精神分裂症患者及其55名亲属、31例首发双相情感障碍患者及其35名亲属，以及113名非精神科受试者及其42名亲属的静息脑电图（EEG）。对于其中106名受试者组成的一个亚组，在间隔约9个月的时间里进行了两次测试，EEG的频率特征显示出适度的稳定性。精神分裂症患者和双相情感障碍患者均表现出δ波和θ波增加、α波活动减少的普遍模式。双相情感障碍患者表现出额外的右半球活动，而精神分裂症患者和非精神科受试者中不存在这种活动，这一发现与关于非优势半球参与调节欣快情绪的假设一致。精神分裂症患者的女性亲属和/或患有情感障碍的亲属以及双相情感障碍患者的α波峰值频率显著降低。这一发现可能与这些受试者信息处理能力下降有关。
