Lundell M, Hakulinen T, Holm L E
Department of Hospital Physics, Karolinska Hospital, Stockholm, Sweden.
Radiat Res. 1994 Dec;140(3):334-9.
A Swedish cohort of 14,351 infants exposed to ionizing radiation for skin hemangioma was analyzed with respect to thyroid cancer risk. The subjects were irradiated during the period 1920-1959 and radiotherapy was given with beta particles, gamma rays and/or X rays. The mean absorbed dose to the thyroid was 0.26 Gy (range < 0.01-28.5 Gy). The cohort was matched with the Swedish Cancer Register for the period 1958-1986. Seventeen thyroid cancers were registered (standardized incidence ratio = 2.28; 95% confidence interval 1.33-3.65), and the mean thyroid absorbed dose in those subjects was 1.07 Gy (range < 0.01-4.34 Gy). The effect of different variables on the incidence of thyroid cancer was evaluated with Poisson regression. The excess in thyroid cancer began 19 years after radiotherapy and persisted at least 40 years after irradiation. A statistically significant dose-response relationship was found. The excess relative risk per gray was 4.92 (95% CI 1.26-10.2) and the excess absolute risk was 0.90 x 10(-4) per person-year gray. No significant difference in excess relative or absolute risk could be seen between the sexes.
对瑞典14351名因皮肤血管瘤接受电离辐射的婴儿队列进行了甲状腺癌风险分析。这些受试者在1920年至1959年期间接受了辐射，放疗使用了β粒子、γ射线和/或X射线。甲状腺的平均吸收剂量为0.26 Gy（范围<0.01 - 28.5 Gy）。该队列与瑞典癌症登记处1958年至1986年期间的数据进行了匹配。登记了17例甲状腺癌（标准化发病率比 = 2.28；95%置信区间1.33 - 3.65），这些受试者的甲状腺平均吸收剂量为1.07 Gy（范围<0.01 - 4.34 Gy）。用泊松回归评估了不同变量对甲状腺癌发病率的影响。甲状腺癌的超额发病在放疗后19年开始，并且在辐射后至少持续了40年。发现了具有统计学意义的剂量反应关系。每格雷的超额相对风险为4.92（95% CI 1.26 - 10.2），每人年每格雷的超额绝对风险为0.90×10⁻⁴。男女之间在超额相对风险或绝对风险方面没有显著差异。
