van Oostayen J A, Wasser M N, van Hogezand R A, Griffioen G, de Roos A
Department of Diagnostic Radiology, University Hospital Leiden, The Netherlands.
Radiology. 1994 Nov;193(2):551-4. doi: 10.1148/radiology.193.2.7972778.
To test the hypothesis that increased blood flow in the superior mesenteric artery (SMA) reflects disease activity in patients with Crohn disease.
Duplex Doppler sonographic measurements of SMA blood flow volume were obtained in 10 patients with active Crohn disease, 10 patients with chronic inactive Crohn disease, and 10 healthy volunteers. Disease activity was determined with clinical and laboratory indicators.
Interstudy reproducibility of repeated SMA flow volume measurements was good (r = .98). A marked increase in SMA flow volume was noted in patients with active disease compared with patients with inactive disease and healthy volunteers: 1,588 mL/min +/- 576 versus 288 mL/min +/- 113 and 417 mL/min +/- 147, respectively (P < .05 for both comparisons).
Activity of Crohn disease causes a substantial increase in SMA flow volume. Measurement of SMA blood flow may be an important noninvasive, readily available, inexpensive tool that can be used to monitor Crohn disease objectively.
检验肠系膜上动脉（SMA）血流量增加反映克罗恩病患者疾病活动度这一假说。
对10例活动期克罗恩病患者、10例慢性非活动期克罗恩病患者及10名健康志愿者进行SMA血流量的双功多普勒超声测量。通过临床及实验室指标确定疾病活动度。
重复测量SMA血流量的研究间可重复性良好（r = 0.98）。与非活动期患者及健康志愿者相比，活动期疾病患者的SMA血流量显著增加：分别为1588 mL/分钟±576、288 mL/分钟±113和417 mL/分钟±147（两组比较P均<0.05）。
克罗恩病活动导致SMA血流量大幅增加。测量SMA血流量可能是一种重要的非侵入性、易于获得且廉价的工具，可用于客观监测克罗恩病。
