Hurtado T, Fernández P, Muñoz Villa A, González M C, García Miguel P
An Esp Pediatr. 1976 Dec;9(9):42-8.
Results obtained by the "cellular synchronization" method in 19 patients are reported; there were five Ewing's sarcomas, three nephroblastomas, nine neuroblastomas and two Burkitt lymphomas. Ages ranged between four months and six years. Most of them had metastatic diseases, resistent to previous therapies. The protocol consisted on vincristine as "synchronizator agent" days 1 and 2, and cyclophosphamide as "effector agent", days 3, 4, 5 and 6 of each pulse. The clinical and hematologic tolerance was generally good. Results were: 12 complete remissions, two partial remissions and three failures.
报告了通过“细胞同步化”方法在19例患者中获得的结果;其中有5例尤因肉瘤、3例肾母细胞瘤、9例神经母细胞瘤和2例伯基特淋巴瘤。年龄在4个月至6岁之间。他们中的大多数患有转移性疾病,对先前的治疗有抗性。方案包括在每个疗程的第1天和第2天使用长春新碱作为“同步剂”,在第3、4、5和6天使用环磷酰胺作为“效应剂”。临床和血液学耐受性总体良好。结果为:12例完全缓解、2例部分缓解和3例失败。