Aquino S L, Gamsu G, Fahy J V, Claster S, Embury S H, Mentzer W C, Vichinsky E P
Department of Radiology, University of California San Francisco 94143-0628.
Radiology. 1994 Dec;193(3):807-11. doi: 10.1148/radiology.193.3.7972829.
To characterize the non-acute abnormalities seen at computed tomography (CT) in patients with sickle cell (SC) disease and a prior history of acute chest syndrome (ACS)-pneumonia.
Twenty-nine patients with SC disease who had experienced one to more than 10 (median, six) previous episodes of ACS-pneumonia were prospectively studied with thin-section CT of the thorax. Scans were graded for interstitial disease and assigned a disease index ranging from 0 to 3. Twenty-four patients underwent pulmonary function tests (PFTs) and measurement of their blood gasses.
Twelve of the 29 patients (41%) had significant interstitial disease that was multifocal. A correlation was found between the disease index and number of episodes of ACS-pneumonia (P = .02) but not between the disease index and PFT results.
Thin-section CT demonstrates significant multifocal interstitial lung abnormalities in 41% of selected patients with SC disease. The pattern is most consistent with scarring from episodes of infarction or infection.
描述镰状细胞（SC）病且有急性胸部综合征（ACS）-肺炎既往史患者在计算机断层扫描（CT）上所见的非急性异常情况。
对29例曾经历过1次至10次以上（中位数为6次）ACS-肺炎发作的SC病患者进行前瞻性胸部薄层CT研究。对扫描结果的间质性疾病进行分级，并赋予0至3的疾病指数。24例患者接受了肺功能测试（PFT）并测定了血气。
29例患者中有12例（41%）存在多灶性显著间质性疾病。发现疾病指数与ACS-肺炎发作次数之间存在相关性（P = 0.02），但疾病指数与PFT结果之间无相关性。
薄层CT显示41%的选定SC病患者存在显著的多灶性间质性肺异常。这种模式最符合梗死或感染发作后的瘢痕形成。
