de Carvalho M G, Rodrigues M A, Marques M E, Franco M, Montenegro M R
Departamento de Patologia, Faculdade de Medicina da Universidade Estadual Paulista (UNESP) Botucatu, SP.
Rev Soc Bras Med Trop. 1994 Jul-Sep;27(3):135-41.
This study was designed to evaluate retrospectively the frequency and etiology of the gastrointestinal (GI) lesions in 45 consecutive necropsies of adult patients with Acquired Immunodeficiency Syndrome (AIDS). Gross descriptions and histological sections of the GI tract, from mouth to anus, were reviewed. The slides were H&E stained, and when necessary special stains and immunohistochemical methods were also employed. There were lesions in GI tract in 37 (82.3%) patients; the mouth was the segment most frequently involved (73.3% of the cases), followed by the colon (55.5%). Multiple lesions occurred in 17 (37.7%) cases. Cytomegalovirus caused colonic lesions in 35.7% of the cases. Candidiasis was observed in 26.6% mainly in the mouth and herpes simplex (8.8%) was the important agent of esophageal lesions. Oral hairy leukoplasia associated with HPV was found in 16 (35.5%) cases. Neoplasia was diagnosed in 7 (15.5%) cases: four Kaposi's sarcoma, two anal intramucosal carcinomas and one gastric lymphoma. Our data confirm the high frequency and variety of GI tract alterations in AIDS.
本研究旨在对45例成年获得性免疫缺陷综合征（AIDS）患者的尸体解剖进行回顾性评估，以确定胃肠道（GI）病变的发生率和病因。对从口腔到肛门的胃肠道进行大体描述和组织学切片检查。切片进行苏木精-伊红（H&E）染色，必要时还采用特殊染色和免疫组织化学方法。37例（82.3%）患者的胃肠道有病变；口腔是最常受累的部位（73.3%的病例），其次是结肠（55.5%）。17例（37.7%）病例出现多处病变。巨细胞病毒导致35.7%的病例出现结肠病变。26.6%的病例观察到念珠菌病，主要在口腔，单纯疱疹（8.8%）是食管病变的重要病因。16例（35.5%）病例发现与人类乳头瘤病毒（HPV）相关的口腔毛状白斑。7例（15.5%）病例诊断为肿瘤：4例卡波西肉瘤、2例肛门黏膜内癌和1例胃淋巴瘤。我们的数据证实了AIDS患者胃肠道改变的高发生率和多样性。
