Meyer H P, Rothuizen J, van den Brom W E, Voorhout G, van Sluijs F J, How K L, Pollak Y W
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
Res Vet Sci. 1994 Jul;57(1):58-62. doi: 10.1016/0034-5288(94)90082-5.
A technique is described for the ultrasound-guided injection of 99mTc-macroaggregates into a splenic vein in order to quantitate portosystemic collateral circulation. The fraction of portal blood by-passing the liver was derived from the radioactivity trapped in the liver and lungs and was expressed as the shunt index (SI). The method was tested in healthy dogs without shunting, and in dogs with single hereditary portosystemic shunts before and one month after surgical closure of the shunt. The mean SI was 0.01 (range 0.01 to 0.05) in healthy dogs and 0.94 (0.69 to 1.00) in dogs with hereditary shunts. After partial closure of the shunts the SI decreased to 0.25 (0.03 to 0.70). There was a significant positive correlation between the logarithms of the concentration of ammonia in plasma and the SI (r = 0.87, P < 0.001).
本文描述了一种在超声引导下将99mTc-大聚合白蛋白注入脾静脉以定量门体侧支循环的技术。绕过肝脏的门静脉血分数由肝脏和肺中捕获的放射性得出，并表示为分流指数（SI）。该方法在无分流的健康犬以及患有单一遗传性门体分流的犬中进行了测试，在手术闭合分流之前和之后一个月进行。健康犬的平均SI为0.01（范围0.01至0.05），遗传性分流犬的平均SI为0.94（0.69至1.00）。部分闭合分流后，SI降至0.25（0.03至0.70）。血浆中氨浓度的对数与SI之间存在显著正相关（r = 0.87，P < 0.001）。
