Zocchi L, Agostoni E
Istituto di Fisiologia Umana I, Università di Milano, Italy.
Respir Physiol. 1994 Aug;97(3):347-56. doi: 10.1016/0034-5687(94)90070-1.
We determined in anesthetised rabbits the net rate of liquid absorption (NRLA) from Ringer or 1% albumin-Ringer hydrothoraces with the beta-blocker propranolol (or nadolol) or the beta-agonist terbutaline. The beta-blocker reduced NRLA by 38% in 2 ml Ringer hydrothoraces, and did not change it in 2 ml albumin-Ringer hydrothoraces; hence, with beta-blocker NRLA became similar in both kinds of hydrothorax (0.31 +/- 0.02 ml/h). Terbutaline decreased NRLA by 25% in 2 ml Ringer hydrothoraces, and increased it by 29% in 2 ml albumin-Ringer hydrothoraces; hence, with terbutaline NRLA became similar in both kinds of hydrothorax (0.40 +/- 0.02 ml/h), and 25% higher than with beta-blocker. Because beta-adrenoreceptor activity inhibits lymphatic smooth muscles and may increase Na+ transport in epithelia, these results suggest that: (1) pleural mesothelium is provided with beta-receptors, which increase Na+ transport and seem activated by protein dilution, (2) beta-receptors of the pleural lymphatics are essentially silent with and without protein dilution, (3) the lymphatic drainage produced by smooth muscle activity is smaller than the increase in solute-coupled liquid absorption caused by mesothelium beta-receptors.
我们在麻醉的兔子身上，使用β受体阻滞剂普萘洛尔（或纳多洛尔）或β受体激动剂特布他林，测定了林格氏液或1%白蛋白 - 林格氏液胸腔内液体的净吸收率（NRLA）。β受体阻滞剂使2毫升林格氏液胸腔的NRLA降低了38%，而在2毫升白蛋白 - 林格氏液胸腔中未使其改变；因此，使用β受体阻滞剂时，两种胸腔的NRLA变得相似（0.31±0.02毫升/小时）。特布他林使2毫升林格氏液胸腔的NRLA降低了25%，而在2毫升白蛋白 - 林格氏液胸腔中使其增加了29%；因此，使用特布他林时，两种胸腔的NRLA变得相似（0.40±0.02毫升/小时），且比特布他林高25%。由于β肾上腺素能受体活性抑制淋巴管平滑肌，并可能增加上皮细胞中的Na⁺转运，这些结果表明：（1）胸膜间皮细胞有β受体，可增加Na⁺转运，且似乎因蛋白质稀释而被激活，（2）无论有无蛋白质稀释，胸膜淋巴管的β受体基本处于静息状态，（3）平滑肌活动产生的淋巴引流小于间皮细胞β受体引起的溶质耦联液体吸收的增加。
