Cuevas-Covarrubias S A, Rojo-Callejas F, Juárez-Oropeza M A, Díaz-Zagoya J C
Depto. de Bioquímica, Facultad de Medicina, UNAM, México, D.F.
Rev Invest Clin. 1994 May-Jun;46(3):197-201.
In this study we analyzed the erythrocyte fatty acid (FA) composition in Mexican children, from 4 to 21 months old with advanced protein-calorie malnutrition. We tried to establish if there were differences in the erythrocyte FA composition of these subjects in comparison with normal children of the same age. The major FA found in children with protein-calorie malnutrition and their controls were (in percentage): stearic (30.6 +/- 5.4 vs 34.8 +/- 2.5), palmitic (22.7 +/- 3.1 vs 25.8 +/- 2.5), oleic (15.9 +/- 3.8 vs 13.1 +/- 3.0), arachidonic (14.8 +/- 4.4 vs 14.1 +/- 4.1), decosatetraenoic (2.4 +/- 2.0 vs 3.7 +/- 2.1) and docosapentaenoic (3.9 +/- 2.2 vs 2.8 +/- 1.7), respectively. There were no intergroup statistical differences in the individual FA between the undernourished and control groups. Saturated FA were 53.2 +/- 6.8% vs 60.6 +/- 7.2%, monounsaturated FA 17.0 +/- 4.1% vs 13.7 +/- 3.0% and polyunsaturated FA 23.7 +/- 5.5% vs 21.1 +/- 4.8% for undernourished and control groups, respectively. Long-chain unsaturated FA values presented the highest variation in both groups, i.e. the unsaturated/saturated FA ratio was 0.76 +/- 0.2 for the undernourished and 0.53 +/- 0.2 for the control group (p < 0.05). Thus, the higher unsaturated/saturated FA ratio in the undernourished was the only change in erythrocyte FA composition observed.
在本研究中，我们分析了4至21个月大患有重度蛋白质 - 热量营养不良的墨西哥儿童的红细胞脂肪酸（FA）组成。我们试图确定这些受试者的红细胞FA组成与同龄正常儿童相比是否存在差异。蛋白质 - 热量营养不良儿童及其对照组中发现的主要脂肪酸（百分比）分别为：硬脂酸（30.6±5.4对34.8±2.5）、棕榈酸（22.7±3.1对25.8±2.5）、油酸（15.9±3.8对13.1±3.0）、花生四烯酸（14.8±4.4对14.1±4.1）、二十碳四烯酸（2.4±2.0对3.7±2.1）和二十二碳五烯酸（3.9±2.2对2.8±1.7）。营养不良组和对照组之间个体脂肪酸的组间无统计学差异。营养不良组和对照组的饱和脂肪酸分别为53.2±6.8%对60.6±7.2%，单不饱和脂肪酸为17.0±4.1%对13.7±3.0%，多不饱和脂肪酸为23.7±5.5%对21.1±4.8%。两组中长链不饱和脂肪酸值的变化最大，即营养不良组的不饱和/饱和脂肪酸比值为0.76±0.2，对照组为0.53±0.2（p<0.05）。因此，营养不良组中较高的不饱和/饱和脂肪酸比值是观察到的红细胞脂肪酸组成的唯一变化。
