Bojalil R
Departamento de Inmunología, Instituto de Investigaciones, Biomédicas, UNAM, México, D.F.
Rev Invest Clin. 1994 Jul-Aug;46(4):323-31.
There is currently a very active research on the mechanisms that give rise to the cell selection of lymphocyte precursors by the thymus. This selection is basic for the process of formation of the repertoire of T cells with which an organism is potentially capable of developing an immune response to a foreign antigen, and not doing so when encountering its own antigens. This work pretends to detail some recent advances in the knowledge of the process by which cells are positively or negatively selected by the thymus, to give rise to the T cell repertoire of an individual.
目前，关于胸腺对淋巴细胞前体进行细胞选择的机制存在非常活跃的研究。这种选择对于T细胞库形成过程至关重要，通过该过程，生物体能够对异源抗原产生免疫反应，而在遇到自身抗原时则不会产生反应。这项工作旨在详述胸腺对细胞进行阳性或阴性选择从而产生个体T细胞库这一过程的最新知识进展。
