Iverson G L, Anderson K W
Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
Scand J Rheumatol. 1994;23(5):277-82. doi: 10.3109/03009749409103729.
The purpose of this review was to explore the probable etiologies of psychiatric problems in patients with SLE. Although instances of psychosis generally are attributed to disease pathophysiology, the precise mechanism for this problem remains speculative. The etiology of non-psychotic psychiatric complaints is even less clear. Overall, it is likely that psychiatric complaints in patients with SLE are attributable to numerous factors including acquired brain dysfunction, organ system dysfunction, iatrogenic effects of corticosteroid treatment, learning history, psychosocial stressors, and current coping strategies. Additional research is needed to explore the bi-directional, synergistic, and dynamic interactions among diverse physiological and psychological variables as they impact an individual's psychiatric status.
本综述的目的是探讨系统性红斑狼疮（SLE）患者出现精神问题的可能病因。虽然精神病发作通常归因于疾病的病理生理机制，但这一问题的确切机制仍属推测。非精神病性精神症状的病因则更不明确。总体而言，SLE患者的精神症状可能归因于多种因素，包括获得性脑功能障碍、器官系统功能障碍、皮质类固醇治疗的医源性影响、学习经历、心理社会压力源以及当前的应对策略。需要进一步研究以探讨不同生理和心理变量之间的双向、协同和动态相互作用，因为它们会影响个体的精神状态。
