Boussiotis V A, Barber D L, Nakarai T, Freeman G J, Gribben J G, Bernstein G M, D'Andrea A D, Ritz J, Nadler L M
Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA 02115.
Science. 1994 Nov 11;266(5187):1039-42. doi: 10.1126/science.7973657.
When stimulated through their antigen receptor without requisite costimulation, T cells enter a state of antigen-specific unresponsiveness termed anergy. In this study, signaling through the common gamma chain of the interleukin-2 (IL-2), IL-4, and IL-7 receptors in the presence of antigen was found to be sufficient to prevent the induction of anergy. After culture with IL-2, IL-4, or IL-7, Jak3 kinase was tyrosine-phosphorylated, which correlated with the prevention of anergy. Therefore, a signal through the common gamma chain may regulate the decision of T cells to either clonally expand or enter a state of anergy.
当T细胞通过其抗原受体受到刺激而无必要的共刺激时，会进入一种称为无反应性的抗原特异性无反应状态。在本研究中，发现在存在抗原的情况下，通过白细胞介素-2（IL-2）、IL-4和IL-7受体的共同γ链进行信号传导足以防止无反应性的诱导。在用IL-2、IL-4或IL-7培养后，Jak3激酶发生酪氨酸磷酸化，这与无反应性的预防相关。因此，通过共同γ链的信号可能调节T细胞克隆性扩增或进入无反应状态的决定。
