Kelner G S, Kennedy J, Bacon K B, Kleyensteuber S, Largaespada D A, Jenkins N A, Copeland N G, Bazan J F, Moore K W, Schall T J
Department of Immunology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, CA 94304.
Science. 1994 Nov 25;266(5189):1395-9. doi: 10.1126/science.7973732.
In this study, the cytokine-producing profile of progenitor T cells (pro-T cells) was determined. During screening of a complementary DNA library generated from activated mouse pro-T cells, a cytokine designated lymphotactin was discovered. Lymphotactin is similar to members of both the Cys-Cys and Cys-X-Cys chemokine families but lacks two of the four cysteine residues that are characteristic of the chemokines. Lymphotactin is also expressed in activated CD8+ T cells and CD4-CD8- T cell receptor alpha beta + thymocytes. It has chemotactic activity for lymphocytes but not for monocytes or neutrophils. The gene encoding lymphotactin maps to chromosome one. Taken together, these observations suggest that lymphotactin represents a novel addition to the chemokine superfamily.
在本研究中，确定了祖T细胞（pro-T细胞）产生细胞因子的情况。在筛选由活化的小鼠pro-T细胞产生的互补DNA文库过程中，发现了一种名为淋巴细胞趋化因子的细胞因子。淋巴细胞趋化因子与Cys-Cys和Cys-X-Cys趋化因子家族的成员相似，但缺少趋化因子特有的四个半胱氨酸残基中的两个。淋巴细胞趋化因子也在活化的CD8+T细胞和CD4-CD8-T细胞受体αβ+胸腺细胞中表达。它对淋巴细胞具有趋化活性，但对单核细胞或中性粒细胞没有趋化活性。编码淋巴细胞趋化因子的基因定位于1号染色体。综上所述，这些观察结果表明淋巴细胞趋化因子是趋化因子超家族的一个新成员。
