National Key Laboratory of Medical Immunology and Institute of Immunology, Naval Medical University, Shanghai 200433, China.
Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200120, China.
Genes (Basel). 2023 Oct 19;14(10):1961. doi: 10.3390/genes14101961.
Chemokines and their receptors play an important role in immune monitoring and immune defense during tumor growth and metastasis. However, their prognostic roles in pan-cancer have not been elucidated. In this work, we screened all chemokine receptors in pan-cancer and discovered X-C Motif Chemokine Receptor 1 () as a reliable immunological and prognostic biomarker in pan-cancer using bioinformation. The TCGA database served as the foundation for the primary research database analysis in this work. XCR1 was downregulated in tumors. Patients with reduced XCR1 showed worse prognoses and a concomitant decrease in immune cell infiltration (DCs and CD8 T cells). According to a gene enrichment study, XCR1 enhanced immune system performance by promoting T-cell infiltration through the C-X-C Motif Chemokine Ligand 9 (CXCL9)- C-X-C Motif Chemokine Receptor 3 (CXCR3) axis. In addition, XCR1 is mainly expressed in infiltrated DCs and some malignant cells in tumor tissues. Our data revealed the important role of XCR1 in remodeling the tumor microenvironment and predicting the survival prognosis, which could also be used as a sensitive biomarker for tumor immunotherapy.
趋化因子及其受体在肿瘤生长和转移过程中的免疫监测和免疫防御中发挥着重要作用。然而，它们在泛癌症中的预后作用尚未阐明。在这项工作中，我们筛选了泛癌症中的所有趋化因子受体，并通过生物信息学发现 X 趋化因子基序趋化因子受体 1（XCR1）是泛癌症中可靠的免疫和预后生物标志物。TCGA 数据库作为本工作中主要研究数据库分析的基础。XCR1 在肿瘤中下调。XCR1 减少的患者预后更差，同时免疫细胞浸润（DC 和 CD8 T 细胞）减少。根据基因富集研究，XCR1 通过 C-X-C 基序趋化因子配体 9（CXCL9）-C-X-C 基序趋化因子受体 3（CXCR3）轴促进 T 细胞浸润，从而增强免疫系统的性能。此外，XCR1 主要在肿瘤组织中浸润的 DC 和一些恶性细胞中表达。我们的数据揭示了 XCR1 在重塑肿瘤微环境和预测生存预后中的重要作用，它也可以作为肿瘤免疫治疗的敏感生物标志物。
