Zhang Y H, Cheng Z F
Department of Physiology Xian Medical University.
Sheng Li Xue Bao. 1994 Aug;46(4):320-6.
Ipsilateral stimulation of the LHb produced a significant attenuation of nociceptive response of wide dynamic range (WDR) neurons in the rat spinal dorsal horn. The inhibitory effect produced by LHb stimulation was partially blocked by systemic cyproheptadine and phentolamine but not naloxone. No significant change was observed in the activity of WDR neurons after ipsilateral electrolytical lesions of the LHb. These results suggest that the LHb participates in the supraspinal descending control on nociceptive response of WDR neurons in the spinal dorsal horn. However, tonic inhibitory mechanism seems not to be involved.
对大鼠外侧缰核（LHb）进行同侧刺激可显著减弱大鼠脊髓背角广动力范围（WDR）神经元的伤害性反应。LHb刺激所产生的抑制作用被全身性赛庚啶和酚妥拉明部分阻断，但未被纳洛酮阻断。对LHb进行同侧电解损伤后，WDR神经元的活动未观察到显著变化。这些结果表明，LHb参与了脊髓背角WDR神经元伤害性反应的脊髓上下行控制。然而，紧张性抑制机制似乎未参与其中。
