Wang G X, Yuan B
Research Laboratory of Neurophysiology, Xi'an Medical University.
Sheng Li Xue Bao. 1994 Apr;46(2):112-9.
The descending pathways for the effects of stimulation of cerebral peduncle (CP) on the nociceptive neurons of spinal cord dorsal horn were analyzed by subtotal spinal cord lesions in anesthetized rats. Inhibition was the predominant effect of CP stimulation on the C-fiber elicited nociceptive responses of dorsal horn neurons, in 30.7% of such neurons, the inhibition was preceded by some initial excitation. In most neurons the inhibitory effect was mediated by both dorsal funiculus (DF) and dorsolateral funiculus (DLF), that of DF usually predominated. It seemed that DLF played a more important role than DF. However, the excitatory effect was mediated by DF alone. Since in the rat the corticospinal tract (CST) is situated in the DF, the results suggest that cerebral cortex can modulate spinal nociceptive transmission not only by the CST, but also through a relay in some supraspinal structure(s) sending descending fibers into the DLF.
通过对麻醉大鼠进行脊髓部分损伤，分析了刺激大脑脚（CP）对脊髓背角伤害性神经元的下行通路。抑制是CP刺激对背角神经元C纤维诱发的伤害性反应的主要效应，在30.7%的此类神经元中，抑制之前有一些初始兴奋。在大多数神经元中，抑制效应由背索（DF）和背外侧索（DLF）共同介导，DF的作用通常占主导。似乎DLF比DF发挥更重要的作用。然而，兴奋效应仅由DF介导。由于在大鼠中皮质脊髓束（CST）位于DF中，结果表明大脑皮层不仅可以通过CST调节脊髓伤害性传递，还可以通过一些将下行纤维发送到DLF的脊髓上结构中的中继来调节。
