Ma C T
Laboratory of Cardiovascular Physiology, Hunan Medical University, Changsha.
Sheng Li Xue Bao. 1994 Aug;46(4):394-8.
A model of hypoxic pulmonary hypertension was made in conscious sheep, and plasma platelet activating factor (PAF) were measured by radioimmunoassay method during the beginning, progression and reversal of hypoxic pulmonary hypertension. The main results were as follows: (1) Under hypoxic condition for 4 days, the conscious sheep develops hypoxemia and marked hypoxic pulmonary vasoconstriction (HPV). These response were reversible. (2) At the beginning of hypoxia, plasma PAF increased, but did not continually increase with hypoxic prolongation and development of HPV. (3) Upon cessation of hypoxia with reversal of pulmonary hypertension, plasma PAF did not show any parallel decrease. These results indicate that plasma PAF is in no way involves in the development of HPV in conscious sheep.
在清醒绵羊身上建立了低氧性肺动脉高压模型，并采用放射免疫分析法在低氧性肺动脉高压的起始、进展和逆转过程中测定血浆血小板活化因子（PAF）。主要结果如下：（1）在低氧4天的条件下，清醒绵羊出现低氧血症和明显的低氧性肺血管收缩（HPV）。这些反应是可逆的。（2）在低氧开始时，血浆PAF升高，但并未随着低氧时间的延长和HPV的发展而持续升高。（3）在低氧停止且肺动脉高压逆转时，血浆PAF并未出现相应下降。这些结果表明，血浆PAF与清醒绵羊HPV的发生无关。
