Segall M, Goetzman B
Division of Neonatology, Children's Hospital, San Diego, California.
Am J Perinatol. 1991 Sep;8(5):300-3. doi: 10.1055/s-2007-999403.
Circulating platelets have been implicated in the hypoxic pulmonary pressor response. This study was undertaken to assess the effects of acute hypoxia-induced pulmonary hypertension on platelet volume and number across the pulmonary circulation in anesthetized newborn lambs. Seven animals were instrumented for measurement of pulmonary vascular resistance. All measurements were made during normoxia and after 5 and 30 minutes of hypoxia (10 to 12% oxygen breathing). Hypoxia caused a doubling of the pulmonary vascular resistance. During hypoxic vasoconstriction, platelet volume decreased rapidly while traversing the lung but was not affected on return to the lung after traversing the systemic circulation. Platelet numbers were unchanged on leaving the lung but were decreased on entering the lung during hypoxia. Our data are consistent with the release of platelet contents in the lung during hypoxic pulmonary hypertension.
循环血小板与低氧性肺升压反应有关。本研究旨在评估急性低氧诱导的肺动脉高压对麻醉新生羔羊肺循环中血小板体积和数量的影响。七只动物被安装仪器以测量肺血管阻力。所有测量均在常氧状态下以及低氧（呼吸10%至12%氧气）5分钟和30分钟后进行。低氧导致肺血管阻力加倍。在低氧性血管收缩期间，血小板在穿过肺部时体积迅速减小，但在穿过体循环后返回肺部时不受影响。离开肺部时血小板数量未变，但在低氧期间进入肺部时血小板数量减少。我们的数据与低氧性肺动脉高压期间肺中血小板内容物的释放一致。
