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[酶联免疫吸附测定法诊断人体囊尾蚴病]

[Diagnosis of human cysticercosis with ELISA].

作者信息

Mondragón A, Plancarte A, Flisser A

机构信息

Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México.

出版信息

Salud Publica Mex. 1994 Jul-Aug;36(4):393-8.

PMID:7973992
Abstract

An analysis of immunodiagnostic data for human cysticercosis by ELISA in 1,052 cerebrospinal fluid (CSF) and serum samples obtained directly from patients or their physicians from different hospitals during 1989-1991, as a result of the diagnostic support service that has been offered to the medical community since 1976, was performed. Overall positivity was 18 per cent. This value was slightly lower when only CSF was analysed (14%) and lowest in the case of serum samples (4%). Analysis of the CSF positivity in ELISA with respect to imaging findings yielded a predictive value of 93 per cent while in cases of excision of cysticerci by neurosurgery 67 per cent sensitivity was obtained. The high positive predictive value, the specificity and the sensitivity of ELISA indicate that this assay is useful to confirm the imaging diagnosis of neurocysticercosis when CSF is used or it can be used as a diagnostic alternative when imaging studies are not available.

摘要

对1989年至1991年期间直接从不同医院的患者或其医生处获取的1052份脑脊液(CSF)和血清样本进行了酶联免疫吸附测定(ELISA),以分析人体囊尾蚴病的免疫诊断数据。这是自1976年以来为医学界提供诊断支持服务的成果。总体阳性率为18%。仅分析脑脊液时,该值略低(14%),血清样本的阳性率最低(4%)。ELISA法检测脑脊液阳性结果与影像学检查结果的分析显示,预测值为93%,而在神经外科手术切除囊尾蚴的病例中,敏感性为67%。ELISA法的高阳性预测值、特异性和敏感性表明,当使用脑脊液时,该检测方法有助于确诊神经囊尾蚴病的影像学诊断,或者在无法进行影像学检查时,可作为一种诊断选择。

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