Benoist M R, Siguier C, Jean R, Fermanian J, Paupe J, Vialatte J
Bull Eur Physiopathol Respir. 1976 Nov-Dec;12(6):703-14.
Functional residual capacity (FRC), dynamic lung compliance (CLdyn) and lung resistance (RL) were measured in a group of 51 healthy children aged 18 months to 6 years (group A) and in a group of 69 survivors of the respiratory distress syndrome (RDS) of the same age (group B). Forty-four per cent of the latter had clinical and radiological abnormalities. In the healthy children significant correlations were found between FRC and height (p less than 0.01), CLdyn and height (P less than 0.01) and CLdyn and FRC (p less than 0.01) but a poor correlation existed between RL and height (p greater than 0.05). There was no significant difference between groups A and B in the slopes of the regression lines for FRC, CLdyn and RL against height, but the intercept for the regression lines relating to CLdyn and RL was lower in group B than in group A. Group B was divided into two subgroups according to the length of exposure to artificial ventilation with an FIO2 in excess of 60 %. A lower value for CLdyn was found in the sub-group with the longer exposure (greater than 120 hours) to a high FIO2, suggesting that this is an additional factor in causing lung damage.
对一组51名年龄在18个月至6岁的健康儿童（A组）和一组69名同年龄段呼吸窘迫综合征（RDS）幸存者（B组）进行了功能残气量（FRC）、动态肺顺应性（CLdyn）和肺阻力（RL）的测量。后者中有44%存在临床和放射学异常。在健康儿童中，发现FRC与身高之间存在显著相关性（p<0.01），CLdyn与身高之间存在显著相关性（P<0.01），CLdyn与FRC之间存在显著相关性（p<0.01），但RL与身高之间的相关性较差（p>0.05）。A组和B组在FRC、CLdyn和RL与身高的回归线斜率方面没有显著差异，但B组中与CLdyn和RL相关的回归线截距低于A组。根据暴露于高于60%的FIO₂的人工通气时间长短，将B组分为两个亚组。在暴露于高FIO₂时间较长（大于120小时）的亚组中发现CLdyn值较低，这表明这是导致肺损伤的一个额外因素。
