Kimber I
Zeneca Central Toxicology Laboratory, Macclesfield, Cheshire, UK.
Toxicology. 1994 Sep 22;93(1):1-11. doi: 10.1016/0300-483x(94)90192-9.
Sensitization to chemicals and the elicitation of allergic reactions results from the stimulation of specific immune responses. Adaptive immunity is orchestrated by cytokines, a family of inducible glycoproteins that influence in many ways the behaviour of, and interaction between, cells which mediate immune and inflammatory responses. In this article the role of cytokines in the development of cutaneous immune responses to chemical allergens and in directing the quality of immune responses provoked by such materials is discussed.
对化学物质的致敏作用以及过敏反应的引发是由特定免疫反应的刺激导致的。适应性免疫由细胞因子精心调控，细胞因子是一类可诱导的糖蛋白家族，它们在许多方面影响介导免疫和炎症反应的细胞的行为及其相互作用。本文讨论了细胞因子在皮肤对化学过敏原的免疫反应发展中以及在指导此类物质引发的免疫反应质量方面所起的作用。
