Faculty of Life Sciences, Toxicology Group, University of Manchester, Manchester M13 9PT, UK.
Contact Dermatitis. 2012 Oct;67(4):179-83. doi: 10.1111/j.1600-0536.2012.02148.x. Epub 2012 Jul 14.
It is well established that, in common with other adaptive immune responses, the acquisition of skin sensitization is carefully orchestrated and finely controlled. This is achieved in a number of ways. However, in recent years, there has been an increasing interest in the roles that regulatory T cells (Tregs) play in allergic contact dermatitis. Here, we review briefly the phenotype and function of Tregs, and consider how they may impact on various aspects of skin sensitization, including: inter-individual differences in susceptibility; variations in the potency of chemical allergens; and the prevention of excessive, and potentially damaging, levels of sensitization.
众所周知，与其他适应性免疫反应一样，皮肤致敏的获得是经过精心协调和精细控制的。这通过多种方式实现。然而，近年来，人们对调节性 T 细胞（Tregs）在过敏性接触性皮炎中的作用越来越感兴趣。在这里，我们简要回顾 Tregs 的表型和功能，并考虑它们如何影响皮肤致敏的各个方面，包括：个体易感性的差异；化学变应原效力的变化；以及防止过度和潜在有害的致敏水平。
