Whitten P L, Russell E, Naftolin F
Department of Anthropology, Emory University, Atlanta, Georgia 30322.
Steroids. 1994 Jul;59(7):443-9. doi: 10.1016/0039-128x(94)90014-0.
The influence of coumestrol on the action of estradiol was examined in oral and parenteral tests. Coumestrol did not antagonize the uterotrophic action of estradiol when administered either prior to, or jointly with, E2 treatment, or when administered orally or parenterally. Additive effects on estradiol stimulation of uterine weight and reduction of cytosolic estrogen receptor binding were observed following oral, but not parenteral, administration of coumestrol. On the other hand, coumestrol pretreatment did appear to dampen estradiol's induction of progestin receptors, uterine protein, and nuclear estrogen receptor binding. However, even at those endpoints where coumestrol pretreatment did dampen estradiol action, coumestrol itself produced an estrogenic response. These findings contradict the assumption that all phytoestrogens are necessarily antiproliferative agents and argue for specific identification of the actions of each chemical.
通过口服和非肠道给药试验研究了香豆雌酚对雌二醇作用的影响。当在雌二醇治疗前、与雌二醇联合给药、口服或非肠道给药时，香豆雌酚均未拮抗雌二醇的子宫营养作用。口服香豆雌酚后观察到对雌二醇刺激子宫重量增加以及胞质雌激素受体结合减少有相加作用，但非肠道给药时未观察到。另一方面，香豆雌酚预处理似乎确实减弱了雌二醇对孕激素受体、子宫蛋白和核雌激素受体结合的诱导作用。然而，即使在香豆雌酚预处理减弱雌二醇作用的那些终点，香豆雌酚本身也产生了雌激素反应。这些发现与所有植物雌激素必然是抗增殖剂的假设相矛盾，并支持对每种化学物质的作用进行具体鉴定。
