Güler A H, Sapan N, Ediz B, Genç Z, Ozkan K
Department of Biochemistry, Uludag University Faculty of Medicine, Görükle, Bursa.
Turk J Pediatr. 1994 Jul-Sep;36(3):205-13.
This study was planned to investigate the effects of copper (Cu) deficiency on liver and bone metabolism in malnourished children. Serum total calcium (Ca), inorganic phosphorus (P), Ca/P, Cu/Ca, Cu/P ratios and alkaline phosphatase (ALP) activity values were analyzed. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyltransferase (GGT) enzyme activities and the ALT/AST (De Ritis) ratio as well as their correlations with Cu were tested to determine liver function. The results of the study showed that Cu deficiency directly affects the organic matrix formation, and by the suppression of ALP activity, indirectly causes decalcification. In the liver, however, no direct effect of Cu deficiency was seen. Deterioration in liver function and Cu deficiency increased parallel with the severity of malnutrition. Thus we concluded that a correlation exists between Cu and the parameters that indicate liver function.
本研究旨在调查铜（Cu）缺乏对营养不良儿童肝脏和骨骼代谢的影响。分析了血清总钙（Ca）、无机磷（P）、Ca/P、Cu/Ca、Cu/P比值以及碱性磷酸酶（ALP）活性值。检测了天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、γ-谷氨酰转移酶（GGT）的酶活性以及ALT/AST（德瑞蒂斯）比值及其与铜的相关性，以确定肝功能。研究结果表明，铜缺乏直接影响有机基质的形成，并通过抑制ALP活性间接导致脱钙。然而，在肝脏中未观察到铜缺乏的直接影响。肝功能恶化与铜缺乏与营养不良的严重程度平行增加。因此，我们得出结论，铜与指示肝功能的参数之间存在相关性。
