Güler A, Sapan N, Salantur E
Department of Biochemistry, Uludağ University Faculty of Medicine, Bursa.
Turk J Pediatr. 1992 Jan-Mar;34(1):21-9.
A protein-energy deficit produces stress in the organism affecting all systems. Proportional to the degree of disease, cortisol and GH are mostly responsible for some of these effects. To investigate the effects on liver and bone, cortisol, GH, AST, ALT, ALP activities and Ca(T) and P(i) in serum were measured in 21 marasmus, nine kwashiorkor and 34 control children. In the marasmus group, we found a positive correlation between cortisol and AST, ALT and Ca(T) and a negative correlation between cortisol and ALP. In the kwashiorkor group there were positive correlations between the same parameters, although, they were of a lesser degree. Furthermore, in the kwashiorkor group we established a positive correlation between GH and ALP. Cortisol stimulates transaminases directly and suppresses ALP activity, thus indirectly increasing Ca(T), whereas GH has no direct effect on these enzymes. As the disease progresses and as liver functions deteriorate, AST, ALT and ALP increase in serum.
蛋白质 - 能量缺乏会给机体带来压力，影响所有系统。与疾病程度成正比，皮质醇和生长激素在这些影响中起主要作用。为了研究对肝脏和骨骼的影响，我们测量了21名消瘦儿童、9名夸希奥科病儿童和34名对照儿童血清中的皮质醇、生长激素、天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、碱性磷酸酶（ALP）活性以及总钙（Ca(T)）和无机磷（P(i)）。在消瘦组中，我们发现皮质醇与AST、ALT和Ca(T)呈正相关，与ALP呈负相关。在夸希奥科病组中，相同参数之间也呈正相关，不过程度较轻。此外，在夸希奥科病组中，我们发现生长激素与ALP呈正相关。皮质醇直接刺激转氨酶并抑制ALP活性，从而间接增加Ca(T)，而生长激素对这些酶没有直接影响。随着疾病进展和肝功能恶化，血清中的AST、ALT和ALP会升高。
