Gürgey A, Yüce A, Ozbek N, Koçak N
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara.
Turk J Pediatr. 1994 Jul-Sep;36(3):259-62.
Autoimmune hemolytic anemia may occur in the course of some viral diseases such as Coxsackie virus, cytomegalovirus, Epstein Barr virus, Influenza A, herpes simplex virus, and rarely hepatitis B virus infection. The role of being heterozygous for beta-thalassemia in hemolysis during acute viral hepatitis is not known. In this report, we present an eight-year-old boy with jaundice and anemia. The diagnosis of hepatitis B virus infection and hemolytic anemia were made on the basis of physical and laboratory findings. A hemoglobin electrophoresis revealed that the child was heterozygous for beta-thalassemia. No specific etiology could be found for hemolytic anemia. It remained unclear whether hemolytic anemia in this patient was merely a coincidental finding or whether hepatitis B virus infection and beta-thalassemia trait had played a role in causing hemolysis.
自身免疫性溶血性贫血可能发生在某些病毒性疾病过程中，如柯萨奇病毒、巨细胞病毒、爱泼斯坦-巴尔病毒、甲型流感病毒、单纯疱疹病毒感染，以及罕见的乙型肝炎病毒感染。β地中海贫血杂合子在急性病毒性肝炎溶血过程中的作用尚不清楚。在本报告中，我们介绍了一名患有黄疸和贫血的8岁男孩。根据体格检查和实验室检查结果做出了乙型肝炎病毒感染和溶血性贫血的诊断。血红蛋白电泳显示该儿童为β地中海贫血杂合子。未发现溶血性贫血的具体病因。尚不清楚该患者的溶血性贫血仅仅是一个偶然发现，还是乙型肝炎病毒感染和β地中海贫血特质在溶血过程中发挥了作用。
