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斯科特天芥菜(Heliotropium scottae Rendle)对小鼠的急性毒性研究。

An acute toxicity study of Heliotropium scottae Rendle in mice.

作者信息

Wahome W M, Muchiri D J, Mugera G M

机构信息

Faculty of Veterinary Medicine, University of Nairobi, Kenya.

出版信息

Vet Hum Toxicol. 1994 Aug;36(4):295-7.

PMID:7975130
Abstract

Twenty-four hour ip median lethal doses (LD50) of freeze-dried aqueous extracts of Heliotropium scottae Rendle leaves and stems in mice were determined and clinical signs noted. The LD50 of the leaf extract was 3.0 g/kg, while that of the stems was 3.5 g/kg. Clinical signs were excitement, prostration, rapid breathing, gasping for breath and death. The signs were the same for both the leaf and stem extracts. It was concluded that both the leaves and stems of H scottae have slight acute toxicity.

摘要

测定了斯科特天芥菜(Heliotropium scottae Rendle)叶和茎的冻干水提取物对小鼠的24小时腹腔半数致死剂量(LD50),并记录了临床症状。叶提取物的LD50为3.0克/千克,而茎提取物的LD50为3.5克/千克。临床症状包括兴奋、虚脱、呼吸急促、喘息和死亡。叶提取物和茎提取物的症状相同。得出的结论是,斯科特天芥菜的叶和茎都有轻微的急性毒性。

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