Mercier P, Chicheportiche C, Reviron D, Dabanian C, Bourgue F, Chiaroni J, Diallo M, Delord Y
Centre Régional de Transfusion Sanguine de Marseille, France.
Vox Sang. 1994;67(1):46-51. doi: 10.1111/j.1423-0410.1994.tb05037.x.
A new case of rare neonatal alloimmune thrombocytopenia, due to an IgG anti-HPA-1b in a mother HPA-1 (a+, b-), was diagnosed using monoclonal antibody-specific immobilization of platelet antigens. Clinically, it was similar to the 2 previously reported observations and confirmed that, in this particular case of anti-HPA-1b, the treatment with random platelet pools may be as effective as selected single-donor platelet units when maternal platelets are unusable. The HLA-DR, -DQ, -DP genotypes of the family were obtained by PCR-SSO. The mother's typing, compared to the HLA-DR of the 6 similar cases reported in Europe, suggests that a combined effect of two rare HLA haplotypes might enhance this immunization.
通过血小板抗原单克隆抗体特异性固定法诊断出一例罕见的新生儿同种免疫性血小板减少症新病例，其病因是母亲HPA-1（a +，b-）中的IgG抗HPA-1b。临床上，该病例与之前报道的2例观察结果相似，并证实，在这种抗HPA-1b的特殊病例中，当母亲的血小板不可用时，使用随机血小板库进行治疗可能与选择单个供体血小板单位一样有效。通过PCR-SSO获得了该家庭的HLA-DR、-DQ、-DP基因型。与欧洲报道的6例类似病例的HLA-DR相比，母亲的分型表明两种罕见的HLA单倍型的联合作用可能会增强这种免疫反应。
