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由于纯合子HPA-1a母亲和纯合子HPA-1b父亲之间的母婴HPA-1不相容性导致的新生儿同种免疫性血小板减少症。病例报告。

Neonatal allo-immune thrombocytopenia due to fetomaternal HPA-1 incompatibility of a homozygous HPA-1a mother and a homozygous HPA-1b father. A case report.

作者信息

Moser R, Fae I, Neumeister A, Pober M, Mutz I, Panzer S

机构信息

Department of Paediatrics, Krankenhaus Loeben, Austria.

出版信息

Eur J Pediatr. 1994 Feb;153(2):95-7. doi: 10.1007/BF01959215.

DOI:10.1007/BF01959215
PMID:8157033
Abstract

We report a case of neonatal allo-immune thrombocytopenia due to fetomaternal human platelet antigen (HPA)-1 incompatibility. Anit-HPA-1b antibodies were detectable in maternal serum. Repeated treatment of the infant with high-dose IgG effectively raised platelet counts transiently, but the patient remained thrombocytopenic for more than 6 weeks. Serological and DNA analysis revealed that the mother was homozygous HPA-1a and the father homozygous HPA-1b.

摘要

我们报告一例因母胎人类血小板抗原（HPA）-1不相容导致的新生儿同种免疫性血小板减少症。在母体血清中可检测到抗HPA-1b抗体。用高剂量免疫球蛋白反复治疗婴儿可使血小板计数暂时有效升高，但该患者血小板减少持续超过6周。血清学和DNA分析显示，母亲为HPA-1a纯合子，父亲为HPA-1b纯合子。

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本文引用的文献

1
Genotyping provides a reliable tool for the determination of the platelet antigen system HPA-1 in Glanzmann's thrombasthenia.基因分型为诊断血小板无力症中的血小板抗原系统HPA-1提供了一种可靠的工具。
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High-dose intravenous immunoglobulin for post-transfusion purpura.大剂量静脉注射免疫球蛋白治疗输血后紫癜
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Alloimmune thrombocytopenia. Review from a neonatal intensive care unit.
同种免疫性血小板减少症。来自新生儿重症监护病房的综述。
Curr Stud Hematol Blood Transfus. 1986(52):87-96.
4
Neonatal alloimmune thrombocytopenia due to fetomaternal Zwb incompatibility.由于胎儿与母体Zwb血型不相容导致的新生儿同种免疫性血小板减少症。
Vox Sang. 1986;50(2):94-6. doi: 10.1111/j.1423-0410.1986.tb04853.x.
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Neonatal alloimmune amegakaryocytosis. Case report.
Vox Sang. 1988;54(2):112-4. doi: 10.1111/j.1423-0410.1988.tb01627.x.
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348 cases of suspected neonatal alloimmune thrombocytopenia.348例疑似新生儿同种免疫性血小板减少症病例。
Lancet. 1989 Feb 18;1(8634):363-6. doi: 10.1016/s0140-6736(89)91733-9.
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HPA-5b (Br(a)) neonatal alloimmune thrombocytopenia: clinical and immunological analysis of 39 cases.HPA-5b（Br(a)）新生儿同种免疫性血小板减少症：39例临床与免疫学分析
Br J Haematol. 1991 Jul;78(3):425-9. doi: 10.1111/j.1365-2141.1991.tb04459.x.
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Leucine33-proline33 substitution in human platelet glycoprotein IIIa determines HLA-DRw52a (Dw24) association of the immune response against HPA-1a (Zwa/PIA1) and HPA-1b (Zwb/PIA2).
Hum Immunol. 1992 Aug;34(4):253-6. doi: 10.1016/0198-8859(92)90024-h.