Karmańska K, Houszka M
Instytut Parazytologii im. Witolda Stefańskiego PAN, Wrocław.
Wiad Parazytol. 1994;40(2):133-40.
The authors tried to determine the role of TH lymphocytes in the course of muscular trichinellosis in mice. The investigations were carried out on the CFW mice infected with 200 Trichinella spiralis larvae and treated with Cyclosporine A to suppress TH1 lymphocytes. In animals treated with the drug more numerous cells inside the larval capsules and more numerous granulomas compared to control were seen. At the same time the mean number of larvae was lower (69.2%) than in control. The results show that TH1 lymphocytes do not play the significant role in the destruction of muscular larvae. This is the first conclusion and requires of course further investigations.
作者试图确定TH淋巴细胞在小鼠肌肉旋毛虫病病程中的作用。研究是在感染200条旋毛虫幼虫并用环孢素A治疗以抑制TH1淋巴细胞的CFW小鼠身上进行的。与对照组相比，在用该药物治疗的动物中，幼虫包囊内的细胞更多，肉芽肿也更多。同时，幼虫的平均数量比对照组低（69.2%）。结果表明，TH1淋巴细胞在肌肉幼虫的破坏中不起重要作用。这是第一个结论，当然还需要进一步研究。
