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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Collodi P, Miranda C L, Zhao X, Buhler D R, Barnes D W

Department of Biochemistry and Biophysics, Oregon State University, Corvallis.

Xenobiotica. 1994 Jun;24(6):487-93. doi: 10.3109/00498259409043251.

Induction of zebrafish P450 by 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) was studied in liver tissue, primary liver cell culture and multipassage cell culture derived from zebrafish haploid and diploid embryos and liver. 2. TCDD induced two hepatic proteins (54 and 50 kDa) in vivo which were recognized by anti-trout P4501A1 IgG. The 54-kDa protein was induced by TCDD in primary and multipassage hepatocyte cultures and in haploid and diploid embryo-derived cells. The proteins in liver homogenates were not induced by aqueous exposure of zebrafish to beta-naphthoflavone (BNF). 3. Homogenates of zebrafish liver, cultured hepatocytes and embryo-derived cells also exhibited increased ethoxyresorufin O-deethylase (EROD) and 7-12-dimethyl-benz[a]anthracene (DMBA) hydroxylase activity following TCDD exposure.

在源自斑马鱼单倍体和二倍体胚胎及肝脏的肝组织、原代肝细胞培养物和多次传代细胞培养物中，研究了2,3,7,8 - 四氯二苯并 - 对 - 二噁英（TCDD）对斑马鱼细胞色素P450的诱导作用。2. TCDD在体内诱导了两种肝脏蛋白（54 kDa和50 kDa），它们可被抗鳟鱼P4501A1 IgG识别。54 kDa的蛋白在原代和多次传代肝细胞培养物以及单倍体和二倍体胚胎来源的细胞中被TCDD诱导。斑马鱼经β - 萘黄酮（BNF）水相暴露后，肝脏匀浆中的蛋白未被诱导。3. TCDD暴露后，斑马鱼肝脏、培养的肝细胞和胚胎来源细胞的匀浆中乙氧基异吩唑酮 - O - 脱乙基酶（EROD）和7,12 - 二甲基苯并[a]蒽（DMBA）羟化酶活性也有所增加。

Collodi P, Miranda C L, Zhao X, Buhler D R, Barnes D W

Department of Biochemistry and Biophysics, Oregon State University, Corvallis.

Xenobiotica. 1994 Jun;24(6):487-93. doi: 10.3109/00498259409043251.

Induction of zebrafish P450 by 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) was studied in liver tissue, primary liver cell culture and multipassage cell culture derived from zebrafish haploid and diploid embryos and liver. 2. TCDD induced two hepatic proteins (54 and 50 kDa) in vivo which were recognized by anti-trout P4501A1 IgG. The 54-kDa protein was induced by TCDD in primary and multipassage hepatocyte cultures and in haploid and diploid embryo-derived cells. The proteins in liver homogenates were not induced by aqueous exposure of zebrafish to beta-naphthoflavone (BNF). 3. Homogenates of zebrafish liver, cultured hepatocytes and embryo-derived cells also exhibited increased ethoxyresorufin O-deethylase (EROD) and 7-12-dimethyl-benz[a]anthracene (DMBA) hydroxylase activity following TCDD exposure.

在源自斑马鱼单倍体和二倍体胚胎及肝脏的肝组织、原代肝细胞培养物和多次传代细胞培养物中，研究了2,3,7,8 - 四氯二苯并 - 对 - 二噁英（TCDD）对斑马鱼细胞色素P450的诱导作用。2. TCDD在体内诱导了两种肝脏蛋白（54 kDa和50 kDa），它们可被抗鳟鱼P4501A1 IgG识别。54 kDa的蛋白在原代和多次传代肝细胞培养物以及单倍体和二倍体胚胎来源的细胞中被TCDD诱导。斑马鱼经β - 萘黄酮（BNF）水相暴露后，肝脏匀浆中的蛋白未被诱导。3. TCDD暴露后，斑马鱼肝脏、培养的肝细胞和胚胎来源细胞的匀浆中乙氧基异吩唑酮 - O - 脱乙基酶（EROD）和7,12 - 二甲基苯并[a]蒽（DMBA）羟化酶活性也有所增加。