斑马鱼的DNA修复能力。
DNA repair capacity of zebrafish.
作者信息
Sussman Raquel
机构信息
Marine Biological Laboratory, Woods Hole, MA 02543, USA.
出版信息
Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13379-83. doi: 10.1073/pnas.0706157104. Epub 2007 Aug 8.
Abstract
Damage to the genome is unavoidable in living creatures, because of sunlight exposure as well as environmental chemicals present in food and drinking water. There is a need to monitor and purify the drinking water; therefore, several methods of detection have been developed. A very promising model system for this purpose is the zebrafish (Danio rerio), which is endowed with special qualities for detecting external as well as internal abnormalities. Grossman and Wei's assay [Grossman L, Wei Q (1995) Clin Chem 12:1854-1863], which measures the expression level of a nonreplicating recombinant plasmid DNA containing a UV-damaged luciferase reporter gene, shows that zebrafish can repair chromosomal lesions to a much greater extent than the human population. This vertebrate model is still very promising after possible down-regulation of the DNA repair enzymes.
摘要
由于暴露在阳光下以及食物和饮用水中存在的环境化学物质，生物体内的基因组损伤是不可避免的。因此有必要对饮用水进行监测和净化，为此已经开发了几种检测方法。用于此目的的一个非常有前景的模型系统是斑马鱼（Danio rerio），它具有检测外部和内部异常的特殊能力。格罗斯曼和魏的检测方法[格罗斯曼L，魏Q（1995年）《临床化学》12：1854 - 1863]，该方法测量含有紫外线损伤的荧光素酶报告基因的非复制重组质粒DNA的表达水平，结果表明斑马鱼修复染色体损伤的程度比人类大得多。在DNA修复酶可能下调后，这个脊椎动物模型仍然非常有前景。
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