Meyer T, Verwiebe R, Lorch H, Kreuzer H, Figulla H R
Abteilung Kardiologie und Pulmologie, Universität Göttingen.
Z Kardiol. 1994 Aug;83(8):589-94.
In two patients (24 and 26 years old) with chronic bronchial asthma, allergic rhinitis, peripheral blood eosinophilia of 48% and 51%, respectively, mononeuritis multiplex and abnormal erythrocyte sedimentation rate, Churg-Strauss syndrome was diagnosed. Acute pericarditis with abnormal ECGs and compensatory sinus tachycardia was documented in both cases as a sign of systemic vasculitis. Echocardiography revealed hemodynamically relevant pericardial effusions of 1.3 cm and 2.7-3.2 cm leading in one case to slightly diastolic compression of the right ventricle. The pericardial lesions showed good response to diuretic therapy with furosemide and administration of immunosuppressive agents like cyclophosphamide and azathioprine in combination with corticosteroids. The two presented cases underline that pericardial effusions of hemodynamic significance can be prominent clinical features of Churg-Strauss syndrome.
在两名患者（分别为24岁和26岁）中，患有慢性支气管哮喘、过敏性鼻炎，外周血嗜酸性粒细胞增多分别达48%和51%，出现多发性单神经炎和红细胞沉降率异常，诊断为变应性肉芽肿性血管炎（Churg-Strauss综合征）。两例均记录到急性心包炎伴心电图异常和代偿性窦性心动过速，作为系统性血管炎的体征。超声心动图显示血流动力学上相关的心包积液分别为1.3厘米和2.7 - 3.2厘米，其中1例导致右心室轻度舒张期受压。心包病变对使用呋塞米的利尿治疗以及给予免疫抑制剂如环磷酰胺和硫唑嘌呤联合皮质类固醇治疗反应良好。所呈现的这两个病例强调，具有血流动力学意义的心包积液可能是变应性肉芽肿性血管炎（Churg-Strauss综合征）突出的临床特征。
