Lendon R G, Emery J L
Dev Med Child Neurol Suppl. 1976(37):16-21. doi: 10.1111/j.1469-8749.1976.tb04276.x.
Sixty-three of 95 cords from children with spina bifida aperta had associated heterotopic ganglion cells, usually located in dorsal nerve roots posterior or lateral to the cord. Heterotopic cells were more common in cords with complete or partial diplomyelia, and the largest number was found in the upper sacral region. It is proposed that the heterotopic position of the cells is due to abnormal and delayed migration of neural crest cells during primary neurogenesis. The findings lend support to the concept that in children with myelomeningocele the cord lesion is not due to secondary rupture.
95例开放性脊柱裂患儿的脊髓中，63例伴有异位神经节细胞，这些细胞通常位于脊髓后方或外侧的背神经根。异位细胞在完全或部分脊髓纵裂的脊髓中更为常见，并且在骶骨上部区域数量最多。有人提出，这些细胞的异位位置是由于原神经发生过程中神经嵴细胞异常和延迟迁移所致。这些发现支持了脊髓脊膜膨出患儿的脊髓病变并非继发于破裂的观点。
