Sans-Coma V, Franco D, Durán A C, Arqué J M, Cardo M, Fernández B
Department of Animal Biology (Zoology), Faculty of Science, University of Málaga, Spain.
Acta Anat (Basel). 1994;149(4):255-63. doi: 10.1159/000147586.
We conducted a light-microscopic histologic study of the aortic valves of 224 Syrian hamsters aged between 1 and 771 days. Most of the hamsters examined belonged to a single laboratory-inbred family with a high incidence of bicuspid aortic valves (BAVs). In 146 specimens the aortic valve was tricuspid, and in 107 of them the ventral commissure was more or less fused. The remaining 78 specimens showed a BAV with the aortic sinuses oriented ventrodorsally. In 33 BAVs a raphe was located in the ventral aortic sinus. Cartilaginous foci were present in the aortic valves of 86 specimens, 40-771 days old. The foci were located at two different sites, namely in the ventral wall of the valve and/or in the dorsal aortic sinus. Statistical analyses substantiate that (1) chondrogenesis begins earlier in BAVs, and especially in those having a raphe, than in tricuspid aortic valves and (2) the location of the cartilaginous foci is significantly associated with the morphology of the aortic valve. The present findings support the hypothesis that, in the Syrian hamster, cartilage forms in the aortic valve as a response to locally intense mechanical stimulation.
我们对224只年龄在1至771天之间的叙利亚仓鼠的主动脉瓣进行了光镜组织学研究。大多数接受检查的仓鼠属于一个单一的实验室近交系家族，其二尖瓣主动脉瓣（BAV）发病率很高。在146个标本中，主动脉瓣为三尖瓣，其中107个标本的腹侧连合或多或少融合。其余78个标本显示为BAV，主动脉窦呈腹背向排列。在33个BAV中，腹侧主动脉窦有一条嵴。软骨灶存在于86个年龄在40至771天的标本的主动脉瓣中。这些病灶位于两个不同的部位，即在瓣膜的腹侧壁和/或背侧主动脉窦。统计分析证实：（1）与三尖瓣主动脉瓣相比，软骨形成在BAV中开始得更早，尤其是在有嵴的BAV中；（2）软骨灶的位置与主动脉瓣的形态显著相关。目前的研究结果支持这样的假设，即在叙利亚仓鼠中，主动脉瓣中的软骨是对局部强烈机械刺激的一种反应而形成的。
