Yamamura Y, Ogura T, Yoshimoto T, Nishikawa H, Sakatani M
Gan. 1976 Oct;67(5):669-77.
The usefulness of the cell-wall skeleton of Mycobacterium bovis BCG (BCG-CWS) to the management of malignant pleural effusion is demonstrated in this report. In two patients with malignant pleurisy the oil-attached BCG-CWS reduced the pleural effusion in volume when injected intrapleurally. The following intradermal injections of BCG-CWS into the bilateral upper arms repeated monthly prevented the reaccumulation of the effusion and improved other clinical conditions of the patients. The possible mechanism responsible for this effect is discussed in relation to previous experimental and clinical studies.
本报告证明了牛分枝杆菌卡介苗细胞壁骨架（BCG-CWS）在恶性胸腔积液治疗中的有效性。在两名恶性胸膜炎患者中，胸膜腔内注射附油的BCG-CWS可减少胸腔积液量。随后每月重复在双侧上臂进行BCG-CWS皮内注射，可防止积液再次积聚，并改善患者的其他临床状况。结合以往的实验和临床研究对这种作用的可能机制进行了讨论。
