Fisher E W, Liu M, Lund V J
Professorial Unit, Royal National Throat, Nose and Ear Hospital, London, England.
Acta Otolaryngol. 1994 Jul;114(4):443-6. doi: 10.3109/00016489409126084.
Previous studies of the nasal cycle in laryngectomy patients using rhinomanometric techniques concluded that the cycle was abolished as a result of the cessation of airflow after laryngectomy. This study was performed with 20 postoperative laryngectomy patients (mean time after surgery 4 years, range: 2 weeks to 10 years) and 10 control subjects matched for age and sex (including 2 preoperative patients). Acoustic rhinometry was used to determine minimum nasal cross-sectional area and nasal cavity volume as the indices of nasal patency. Testing was repeated at intervals of 15-30 min over a period of 3-8 h. Fluctuations in nasal patency were observed in all laryngectomees and controls. The fluctuations were classified as 'classical' (reciprocal alternating) in 5 (25%) laryngectomees and 5 (50%) controls. An 'irregular' pattern of fluctuation was seen in 8 (40%) laryngectomees and 2 (20%) controls. An 'in concert' cyclical pattern was seen in 7 (35%) laryngectomees and 3 (30%) controls. This is the first demonstration of retention of the nasal cycle after airflow deprivation. Whilst the cycle may in some instances be modified after operation, it is not abolished. The central generation of the cycle is confirmed, although afferent input from airflow receptors may play a role in modulating the cycle's pattern and amplitude.
以往使用鼻阻力测量技术对喉切除患者鼻周期的研究得出结论，喉切除术后气流停止导致鼻周期消失。本研究对20例喉切除术后患者（术后平均时间4年，范围：2周至10年）和10例年龄和性别匹配的对照者（包括2例术前患者）进行。采用鼻声反射测量法确定最小鼻腔横截面积和鼻腔容积作为鼻通畅度指标。在3 - 8小时内每隔15 - 30分钟重复测试一次。在所有喉切除患者和对照者中均观察到鼻通畅度的波动。5例（25%）喉切除患者和5例（50%）对照者的波动被分类为“经典型”（相互交替）。8例（40%）喉切除患者和2例（20%）对照者出现“不规则”波动模式。7例（35%）喉切除患者和3例（30%）对照者出现“协同”周期性模式。这是气流阻断后鼻周期仍存在的首次证明。虽然该周期在某些情况下术后可能会改变，但并未消失。尽管来自气流感受器的传入输入可能在调节周期的模式和幅度方面起作用，但周期的中枢产生已得到证实。
