Ju D W, Zheng Q Y, Wang H B, Guan X J, Fang J, Yi Y H
Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai.
Yao Xue Xue Bao. 1994;29(4):252-5.
Esculentoside A (EsA) is a kind of saponin isolated from Phytolacca esculenta Van Houtte. It was shown to significantly inhibit phagocytic activity, intracellular and extracellular production of interleukin-1 by thioglycollate primed murine peritoneal macrophages in vitro at the concentration 0.01-1.0 mumol.L-1. In vivo experiments showed that EsA 2.5-5 mg.kg-1 markedly decreased serum hemolysin concentration in sensitized mice challenged with sheep red blood cells. Inhibition of antibody production by B lymphocytes, phagocytosis and the production of inflammatory mediators by macrophages may partially explain the wide and strong anti-inflammatory effect of EsA.
商陆皂苷甲（EsA）是从商陆中分离得到的一种皂苷。研究表明，在体外，浓度为0.01 - 1.0 μmol.L-1时，它能显著抑制巯基乙酸预处理的小鼠腹腔巨噬细胞的吞噬活性以及白细胞介素-1的细胞内和细胞外产生。体内实验表明，2.5 - 5 mg.kg-1的EsA能显著降低用绵羊红细胞攻击的致敏小鼠血清溶血素浓度。B淋巴细胞抗体产生的抑制、巨噬细胞的吞噬作用以及炎症介质的产生可能部分解释了EsA广泛而强大的抗炎作用。
