三唑并二氮杂䓬对小鼠脾细胞和腹腔巨噬细胞的体外抑制作用。
Inhibitory effects of triazolodiazepine on mouse splenocytes and peritoneal macrophages in vitro.
作者信息
Ju D W, Zheng Q Y, Wang H B, Fang J
机构信息
Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai, China.
出版信息
Zhongguo Yao Li Xue Bao. 1994 Jan;15(1):65-8.
Effects of triazolodiazepine (Tri) on mouse splenocyte proliferation and macrophage phagocytosis were studied. Tri 0.1-10 mumol.L-1 significantly inhibited concanavalin A (Con A) 5 micrograms.ml-1 and lipopolysaccharides (LPS) 10 micrograms.ml-1-induced splenocyte proliferation and phagocytic activity of activated peritoneal macrophages. Tri 10 mumol.L-1 reduced Con A-induced colony stimulating factor release from mouse splenocytes and LPS-challenged intracellular and extracellular interleukin-1 production from peritoneal macrophages. These results partially explain the wide and strong anti-inflammatory effects of Tri.
研究了三唑并二氮杂卓（Tri）对小鼠脾细胞增殖和巨噬细胞吞噬作用的影响。0.1 - 10μmol.L-1的Tri显著抑制5μg.ml-1伴刀豆球蛋白A（Con A）和10μg.ml-1脂多糖（LPS）诱导的脾细胞增殖以及活化腹膜巨噬细胞的吞噬活性。10μmol.L-1的Tri减少了Con A诱导的小鼠脾细胞集落刺激因子释放以及LPS刺激的腹膜巨噬细胞细胞内和细胞外白细胞介素-1的产生。这些结果部分解释了Tri广泛而强效的抗炎作用。
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