Wu C B, Wei S L, Lu W, Zhao Y L, Gao W W
School of Pharmaceutical Sciences, Beijing Medical University.
Yao Xue Xue Bao. 1994;29(4):311-5.
The responsiveness and transcatheter embolization with magnetic gelatin microspheres (MG-ms) in dog kidney were reported. In experiments with magnet using a constant flow apparatus such as roller pump, the percent retention was determined by counting the carrier retained by the magnetic field and divided by the total starting counts. Factors influencing the percent retention of MG-ms include: velocity of medium flow, magnetic field intensity, alpha-Fe2O3 content in the MG-ms, viscosity of the medium and so on. Transcatheter embolization with MG-ms (10-30 microns) was performed under external magnet control in dog kidney. The result of angiogram and histological section showed that the MG-ms were in the arteries, arterioles, and glomerular capillaries with no adverse reactions. The embolized effect with magnet field was more prominent than the group without magnet field. These results show that the MG-ms is a promising embolic agent for treatment of renal cancer under external magnet control.
报道了磁性明胶微球（MG-ms）在犬肾中的反应性及经导管栓塞情况。在使用诸如滚轴泵等恒流装置并借助磁体的实验中，通过计数被磁场截留的载体并除以起始总计数来确定截留百分比。影响MG-ms截留百分比的因素包括：介质流速、磁场强度、MG-ms中α-Fe2O3含量、介质粘度等。在外部磁体控制下，对犬肾进行了MG-ms（10 - 30微米）的经导管栓塞。血管造影和组织学切片结果显示，MG-ms存在于动脉、小动脉和肾小球毛细血管中，且无不良反应。有磁场的栓塞效果比无磁场组更显著。这些结果表明，MG-ms是一种在外部磁体控制下治疗肾癌的有前景的栓塞剂。
