Vajda M, Horváthné Otta K, Forgácsné Tóth E
MTA Központi Kémiai Kutató Intézete, Budapest.
Acta Pharm Hung. 1994 Jul;64(4):131-4.
Indosol is the water soluble Trometamol salt of Indomethacin. It shows promise in the combating of inflammations e.g. in ocular surgery. This paper reports on the results obtained using analytical methods of the Hungarian Pharmacopeia and the development of new analytical methods for Indosol. Solvent residues in Indosol were determined gas chromatographically after extraction with carbon tetrachloride, and an HPLC method was developed for the determination of Indosol as a pure substance or in eye-drops, using a Hypersil-ODS column and methanol-water-acetonitrile-acetic acid (55:35:10:5).
吲哚索是吲哚美辛的水溶性 trometamol 盐。它在对抗炎症方面显示出前景，例如在眼科手术中。本文报道了使用匈牙利药典分析方法获得的结果以及吲哚索新分析方法的开发。用四氯化碳萃取后，通过气相色谱法测定吲哚索中的溶剂残留量，并开发了一种 HPLC 方法，使用 Hypersil-ODS 柱和甲醇 - 水 - 乙腈 - 乙酸（55:35:10:5）来测定纯物质或滴眼液中的吲哚索。
