Kahánné L I, Bögi J, Farkas A, Tüdös F H, Imre G
SOTE II. sz. Szemklinika, Budapest.
Acta Pharm Hung. 1994 Jul;64(4):125-9.
For the topical employing of nonsteroidal antiinflammatory drugs, some technological problems are to be solved. These were accomplished by the authors by preparing Indosol [indomethacin-TRIS (tromethamine) salt]. pH and osmotic pressure of Indosol eye-drops are similar to that of the tear fluid. The Indosol eye-drops have a great therapeutic efficacy. Indosol eye-drops do not alter tear film break up time (BUT) and do not inhibit reepithelization of the cornea. Indosol eye-drops proved to be useful in the treatment of the anterior segment and the uvea. The most important use is the pre- and post-treatment in intraocular surgery. Indosol eye-drops contribute to the safety of lens-extraction and lens implantation. The great bioavailability was also shown by the high indomethacin level of the aqueous humor after instillation Indosol eye-drops. It does not cause any deleterious side-effects even in long term treatments.
对于局部使用非甾体抗炎药，需要解决一些技术问题。作者通过制备吲哚索（吲哚美辛-三羟甲基氨基甲烷盐）解决了这些问题。吲哚索滴眼液的pH值和渗透压与泪液相似。吲哚索滴眼液具有很好的治疗效果。吲哚索滴眼液不会改变泪膜破裂时间（BUT），也不会抑制角膜的再上皮化。吲哚索滴眼液被证明可用于眼前节和葡萄膜的治疗。最重要的用途是在眼科手术的术前和术后治疗。吲哚索滴眼液有助于晶状体摘除和晶状体植入的安全性。滴入吲哚索滴眼液后房水中吲哚美辛水平较高，也表明其生物利用度高。即使长期治疗，它也不会引起任何有害的副作用。
