Hata R, Matsumoto M, Yamamoto K, Ohtsuki T, Ogawa S, Handa N, Kubo T, Matsunaga T, Nishimura T, Kamada T
First Department of Internal Medicine, University of Osaka, Japan.
Acta Neurochir Suppl (Wien). 1994;60:197-9. doi: 10.1007/978-3-7091-9334-1_53.
To clarify the effect of vasogenic brain edema on the brainstem, the relationships between waveform changes in brainstem auditory evoked potentials (BAEP) and blood-brain barrier (BBB) disturbance following transient hindbrain ischemia were investigated. Hindbrain ischemia was induced in gerbils by bilateral occlusion of the vertebral arteries. The animals were divided into three groups subjected to 0, 5, and 30 min of bilateral vertebral occlusion (BVO-0',-5', and -30' groups; n = 4 in each group). Two hours after recirculation, Evans blue (EB) solution was injected into the saphenous vein. The brains were removed after 30 min of circulation, and all areas stained macroscopically by EB were noted and recorded. During hindbrain ischemia, BAEP disappeared within 3 min. In the BVO-5' group, BAEP reappeared and returned to normal within 10 min after reperfusion, whereas in the BVO-30' group, BAEP never returned to normal and finally disappeared within 30 min after reperfusion. In the BVO-5' group, no EB staining was visible. On the other hand, in the BVO-30' group, EB staining was seen in the medial part of the tegmentum in the midbrain in two animals, and around the vestibular nucleus in the lateral parts of the pons in three. These results demonstrate the close relationship between the reversibility of ischemia-induced changes in BAEP and BBB disturbance in the brainstem.
为阐明血管源性脑水肿对脑干的影响，研究了短暂性后脑缺血后脑干听觉诱发电位（BAEP）波形变化与血脑屏障（BBB）紊乱之间的关系。通过双侧椎动脉闭塞在沙鼠中诱导后脑缺血。将动物分为三组，分别进行0、5和30分钟的双侧椎动脉闭塞（BVO-0'、-5'和-30'组；每组n = 4）。再灌注2小时后，将伊文思蓝（EB）溶液注入隐静脉。循环30分钟后取出大脑，记录并标记所有肉眼可见的EB染色区域。在后脑缺血期间，BAEP在3分钟内消失。在BVO-5'组中，BAEP在再灌注后10分钟内重新出现并恢复正常，而在BVO-30'组中，BAEP从未恢复正常，最终在再灌注后30分钟内消失。在BVO-5'组中，未见EB染色。另一方面，在BVO-30'组中，两只动物的中脑被盖内侧部分可见EB染色，三只动物的脑桥外侧部分前庭核周围可见EB染色。这些结果表明缺血诱导的BAEP变化的可逆性与脑干BBB紊乱之间存在密切关系。
