Yamasaki Y, Shozuhara H, Onodera H, Kogure K
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Acta Neurochir Suppl (Wien). 1994;60:300-2. doi: 10.1007/978-3-7091-9334-1_80.
We examined the therapeutic value of an interleukin-1 inhibitor on brain edema formation using a transient focal ischemia model in rats. Rats were given an interleukin-1 blocker, or interleukin-1 release inhibitor immediately after reperfusion. In rats treated with interleukin-1 inhibitor, ischemic brain edema 1 day after reperfusion was significantly decreased compared to that of saline-treated control rats. The simultaneous application of an IL-1 release inhibitor and a lipoxygenase inhibitor showed an additive beneficial effect on brain edema formation. These findings suggest that blocking IL-1 activity ameliorates brain edema and attenuates the neuronal damage induced by focal transient ischemia in rats.
我们使用大鼠短暂性局灶性缺血模型研究了白细胞介素-1抑制剂对脑水肿形成的治疗价值。大鼠在再灌注后立即给予白细胞介素-1阻断剂或白细胞介素-1释放抑制剂。与生理盐水处理的对照大鼠相比，用白细胞介素-1抑制剂处理的大鼠在再灌注1天后的缺血性脑水肿明显减轻。白细胞介素-1释放抑制剂和脂氧合酶抑制剂的联合应用对脑水肿形成显示出相加的有益作用。这些发现表明，阻断白细胞介素-1的活性可改善脑水肿，并减轻大鼠局灶性短暂性缺血诱导的神经元损伤。
