钆卟啉在磁共振成像中对实验性脑肿瘤的定位

Localization of experimental brain tumors in MRI by gadolinium porphyrin.

作者信息

Bockhorst K, Els T, Kohno K, Hoehn-Berlage M

机构信息

Department of Experimental Neurology, May-Planck-Institute for Neurological Research, Cologne, Federal Republic of Germany.

出版信息

Acta Neurochir Suppl (Wien). 1994;60:347-9. doi: 10.1007/978-3-7091-9334-1_93.

DOI:10.1007/978-3-7091-9334-1_93

PMID:7976586

Abstract

The contrast between edema and F98 glioma in rat brain was distinctly enhanced in T2-weighted MRI (TE 130 ms, TR 3 s) by intraperitoneal injection of the synthetic gadolinium-porphyrin complex, GdTPPS. The T1 relaxation time of the gliomas was selectively shortened by about 50% from 1339 +/- 109 ms to 628 +/- 106 ms, and the T2 relaxation time was shortened by about 35% from 86 +/- 6 ms to 57 +/- 5 ms. The relaxation times of normal tissues under investigation (cortex, corpus callosum, temporal muscle, ventricles) were unaltered. Therefore, GdTPPS-application causes F98 gliomas to appear hyperintense in T1-weighted MRI and hypointense in T2-weighted MRI.

摘要

通过腹腔注射合成的钆卟啉复合物GdTPPS，大鼠脑内水肿与F98胶质瘤之间的对比度在T2加权磁共振成像（TE 130毫秒，TR 3秒）中明显增强。胶质瘤的T1弛豫时间从1339±109毫秒选择性缩短约50%至628±106毫秒，T2弛豫时间从86±6毫秒缩短约35%至57±5毫秒。所研究的正常组织（皮质、胼胝体、颞肌、脑室）的弛豫时间未改变。因此，应用GdTPPS使F98胶质瘤在T1加权磁共振成像中呈高信号，在T2加权磁共振成像中呈低信号。