实验性脑肿瘤中的质子弛豫增强——大鼠脑胶质瘤中锰（III）四苯基卟啉的体内核磁共振研究

Proton relaxation enhancement in experimental brain tumors--in vivo NMR study of manganese(III)TPPS in rat brain gliomas.

作者信息

Bockhorst K, Höhn-Berlage M, Kocher M, Hossmann K A

机构信息

Max-Planck-Institut für neurologische Forschung, Abteilung für experimentelle Neurologie, Cologne, FRG.

出版信息

Magn Reson Imaging. 1990;8(4):499-504. doi: 10.1016/0730-725x(90)90058-a.

DOI:10.1016/0730-725x(90)90058-a

PMID:2392036

Abstract

The effect of manganese(III)tetraphenylporphine sulfonate (MnTPPS) on the relaxation enhancement of NMR images (MRI) was studied in experimental brain tumors in rats. Brains were inoculated with the glioma cell line F98 12 to 19 days before the NMR experiment, and the effect of MnTPPS (0.25 mmol/kg body weight) was investigated 2 and 4 days after intraperitoneal injection. After MnTPPS addition tumors could be clearly distinguished by the brightness from the surrounding brain whereas they were barely visible without contrast enhancement. At SE time of 25 msec and TR time of 3500 msec the ratio of magnetization values of tumor versus normal grey matter increased from 0.98 +/- 0.08 to 1.24 +/- 0.09 (means +/- SD). When TR was shortened to 1100 msec contrast enhancement further increased to 1.77 +/- 0.25. These results demonstrate for the first time that MnTPPS is an efficient agent for contrast enhancement of brain tumors.

摘要

在大鼠实验性脑肿瘤中研究了四苯基卟啉磺酸锰（MnTPPS）对核磁共振成像（MRI）弛豫增强的影响。在核磁共振实验前12至19天，将胶质瘤细胞系F98接种于大鼠脑内，腹腔注射MnTPPS（0.25 mmol/kg体重）后2天和4天研究其效果。添加MnTPPS后，肿瘤可通过亮度与周围脑组织清晰区分，而未增强造影时几乎不可见。在自旋回波（SE）时间为25毫秒、重复时间（TR）为3500毫秒时，肿瘤与正常灰质的磁化值之比从0.98±0.08增加到1.24±0.09（平均值±标准差）。当TR缩短至1100毫秒时，造影增强进一步增加至1.77±0.25。这些结果首次证明MnTPPS是一种增强脑肿瘤造影的有效试剂。