甘露醇在颅内压升高患者中的药代动力学研究。

Pharmacokinetic study of mannitol in subjects with increased ICP.

作者信息

Kobayashi T, Ichikawa T, Kondo R, Yoshiyama Y, Tomonaga F, Ohwada T

机构信息

School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.

出版信息

Acta Neurochir Suppl (Wien). 1994;60:538-40. doi: 10.1007/978-3-7091-9334-1_148.

DOI:10.1007/978-3-7091-9334-1_148

PMID:7976642

Abstract

Six human subjects received mannitol as an intravenous dip (DIV) infusion. In each subject, the concentration of mannitol and serum osmolality were rapidly elevated during mannitol administration and reached the maximum at the end of mannitol administration. Then, it exponentially decreased. There was a strong positive correlation between mannitol concentration and extrinsic serum osmolality. The integrated values of mannitol concentration difference between the central (Cc) and the peripheral compartment (Pc) correlated with the changes of ICP reduction during mannitol administration. The results indicate that the changes of ICP reduction depend on the mannitol concentration difference between Cc and Pc.

摘要

六名人类受试者接受了静脉滴注（DIV）甘露醇。在每名受试者中，甘露醇给药期间甘露醇浓度和血清渗透压迅速升高，并在甘露醇给药结束时达到最大值。然后，它呈指数下降。甘露醇浓度与外在血清渗透压之间存在强正相关。中心室（Cc）和外周室（Pc）之间甘露醇浓度差的积分值与甘露醇给药期间颅内压降低的变化相关。结果表明，颅内压降低的变化取决于Cc和Pc之间的甘露醇浓度差。