Blair I A, Dougherty R M, Iacono J M
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232-6602.
Am J Clin Nutr. 1994 Dec;60(6 Suppl):1054S-1058S. doi: 10.1093/ajcn/60.6.1054S.
Ten male subjects were fed a diet rich in stearic acid while they were contained to a metabolic ward. There were three study periods: a 20-d baseline period followed by two 40-d intervention periods. The baseline diet contained 4.4% of energy from stearic acid; one intervention diet was high in stearic acid (7.3% of energy) and the other intervention diet was low in stearic acid (1.6% of energy). The energy contribution of protein, carbohydrate, and fat (16%, 54%, and 30%, respectively) was identical for the two diets. The fat content was distributed equally among saturated, monounsaturated, and polyunsaturated fatty acids. Urinary excretions of thromboxane B2, 2,3-dinor-thromboxane B2, 6-oxo-prostaglandin F1 alpha, and 2,3-dinor-6-oxo-prostaglandin F1 alpha were not significantly different during the two different intervention periods. This suggests that changes in dietary stearic acid do not affect in vivo thromboxane A2 or prostacyclin biosynthesis.
十名男性受试者被安置在代谢病房期间，食用富含硬脂酸的饮食。有三个研究阶段：一个为期20天的基线期，随后是两个为期40天的干预期。基线饮食中硬脂酸提供的能量占4.4%；一种干预饮食富含硬脂酸（能量的7.3%），另一种干预饮食硬脂酸含量低（能量的1.6%）。两种饮食中蛋白质、碳水化合物和脂肪的能量贡献（分别为16%、54%和30%）相同。脂肪含量在饱和脂肪酸、单不饱和脂肪酸和多不饱和脂肪酸之间平均分配。在两个不同的干预期内，血栓素B2、2,3-二去甲血栓素B2、6-氧代前列腺素F1α和2,3-二去甲-6-氧代前列腺素F1α的尿排泄量没有显著差异。这表明饮食中硬脂酸的变化不会影响体内血栓素A2或前列环素的生物合成。
