Shulman L P, Emerson D S, Grevengood C, Felker R E, Gross S J, Phillips O P, Elias S
Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38103-2896.
Am J Obstet Gynecol. 1994 Nov;171(5):1278-81. doi: 10.1016/0002-9378(94)90147-3.
We assessed newborn outcome and infant development in cases of first-trimester fetal cystic nuchal lesion and normal karyotype.
Information regarding newborn outcomes and infant growth and development was prospectively obtained from 32 consecutive pregnancies characterized by fetal cystic nuchal lesions detected in the first trimester (< or = 13.9 weeks' gestation) and normal karyotypes.
Cystic nuchal lesions spontaneously resolved by the twentieth gestational week in 31 cases; all 31 infants had normal results at newborn examination and demonstrated normal growth and development at 12 months of age. Resolution did not occur in one case; prominent hygromas were repaired at birth with normal growth and development through 2 1/2 years of age.
In most affected fetuses with normal karyotypes, spontaneous resolution will occur with favorable newborn and infant outcomes. However, patients should be counseled that resolution may not occur or that nonchromosome abnormalities may result in a less favorable outcome.
我们评估了孕早期胎儿囊性颈部病变且核型正常的病例中的新生儿结局及婴儿发育情况。
前瞻性地获取了连续32例妊娠的新生儿结局以及婴儿生长发育信息，这些妊娠的特点是在孕早期（妊娠≤13.9周）检测到胎儿囊性颈部病变且核型正常。
31例中囊性颈部病变在孕20周时自发消退；所有31例婴儿在新生儿检查时结果正常，且在12月龄时生长发育正常。1例未发生消退；出生时对明显的水囊瘤进行了修复，至2岁半时生长发育正常。
在大多数核型正常的受累胎儿中，会发生自发消退，新生儿及婴儿结局良好。然而，应告知患者可能不会发生消退，或者非染色体异常可能导致不太理想的结局。
